Its Patriots’ Day in Boston and that means marathons and late morning baseball with the Red Sox (12-11). Today, Boston wraps up its series with the White Sox (5-16) at Fenway.
Jonathan Cannon is slated to take the mound for Chicago against Walker Buehler for Boston.
The Pale Sox snapped Boston’s four-game win streak yesterday with an 8-4 win. Andrew Vaughn picked up a couple of hits including his third home run of the season to pace the attack for Chicago.
After eight straight losses on the road to open the season, Chicago ends the worst run to start the season away from home in franchise history.
Lets dive into today’s matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.
Game details & how to watch White Sox at Red Sox
- Date: Monday, April 21, 2025
- Time: 11:10AM EST
- Site: Fenway Park
- City: Boston, MA
- Network/Streaming: CHSN, NESN, MLBN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the White Sox at the Red Sox
The latest odds as of Monday:
- Moneyline: White Sox (+228), Red Sox (-280)
- Spread: Red Sox -1.5
- Total: 9.0 runs
Probable starting pitchers for White Sox at Red Sox
- Pitching matchup for April 21, 2025: Jonathan Cannon vs. Walker Buehler
- White Sox: Jonathan Cannon (0-2, 4.42 ERA)
Last outing: 4/16 vs. Athletics – 4.1IP, 0ER, 3H, 2BB, 4Ks - Red Sox: Walker Buehler (2-1, 5.23 ERA)
Last outing: 4/15 at Tampa Bay – 5IP, 2ER, 3H, 3BB, 3Ks
- White Sox: Jonathan Cannon (0-2, 4.42 ERA)
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Top betting trends & insights to know ahead of White Sox at Red Sox
- The Red Sox have won 4 of their last 5 home games against teams with losing records
- The Under is 12-7-1 in the Red Sox’s games against American League teams this season
- Chicago 3B Miguel Vargas is 3 for his last 25 (.120)
- Boston 3B Alex Bregman is 6 for his last 20 (.300)
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for today’s game between the White Sox and the Red Sox
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Monday’s game between the White Sox and the Red Sox:
- Moneyline: NBC Sports Bet is recommending a play on the Boston Red Sox on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago White Sox at +1.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
- Drew Dinsick (@whale_capper)
- Vaughn Dalzell (@VmoneySports)
- Brad Thomas (@MrBradThomas)
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