Scott McTominay is expected to start in central midfield for Napoli despite minor fitness issues with Antonio Conte confirming a 3-5-2 line-up against Fiorentina.
It kicks off at 15:00 CET (14:000 GMT) at the Stadio Maradona.
The Partenopei need a win to keep pace with Inter who beat strugglers Monza 3-2 at San Siro last night.
David Neres, Pasquale Mazzocchi and Frank Anguissa are injured, so Conte is expected to confirm the same team that collected a 1-1 draw against Inter last week with Romelu Lukaku and Giacomo Raspadori in attack.
Fiorentina must cope without Edoardo Bove, Andrea Colpani and Michael Folorunsho, while Rolando Mandragora and Nicolò Zaniolo are suspended.
The Tuscans will slightly rotate as they have a key Conference League game against Panathinaikos next week.
The Viola lost 3-2 in Greece in the Round of 16 first leg last week.
Moise Kean will start up front alongside Lucas Beltran, while David de Gea will return between the sticks after resting in the latest European fixture.
Napoli vs Fiorentina – where to watch on TV
The game will be available to stream live on OneFootball in the UK. FOX Deportes will broadcast the game live in USA, while Paramount+ and FuboTV will show it live in streaming.
Napoli vs Fiorentina – probable line-ups
Napoli (3-5-2): Meret; Di Lorenzo, Rrahmani, Buongiorno; Politano, Gilmour, Lobotka, McTominay, Spinazzola; Lukaku, Raspadori.
Fiorentina (3-5-2): De Gea; Comuzzo, Marí, Ranieri; Dodô, Fagioli, Cataldi, Ndour, Gosens; Beltran, Kean.
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