Reds at Giants prediction: Odds, expert picks, starting pitchers, betting trends, and stats for April 8

Its Tuesday, April 8 and it is Game 2 in the three-game series between the Reds (4-7) and the Giants (8-2) in San Francisco.

Nick Lodolo is slated to take the mound for Cincinnati against Landen Roupp for San Francisco.

The Reds took the series opener 2-0 last night. Hunter Greene was excellent going 8.2 shutout innings allowing just four hits and one walk while striking out seven. Blake Dunn drove in both runs for Cincinnati. Logan Web through seven shutout innings for the Giants.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Reds at Giants

• Date: Tuesday, April 8, 2025
• Time: 9:45PM EST
• Site: Oracle Park
• City: San Francisco, CA
• Network/Streaming: FDSNOH, NBCSBA

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Reds at the Giants

The latest odds as of Tuesday:

• Moneyline: Reds (+101), Giants (-120)
• Spread: Giants -1.5
• Total: 7.0 runs

Probable starting pitchers for Reds at Giants

• Pitching matchup for April 8, 2025: Nick Lodolo vs. Landen Roupp
  • Reds: Nick Lodolo (1-1, 1.42 ERA)
    Last outing: 4/3 at Milwaukee – 6.2IP, 0ER, 4H, 0BB, 4Ks
  • Giants: Landen Roupp (0-0, 6.75 ERA)
    Last outing: 4/2 at Houston – 4IP, 3ER, 4H, 4BB, 8Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Reds at Giants

• The Reds are 6-5 on the Run Line this season
• The Giants 7-game win streak was stopped last night
• The Giants are 7-3 on the Run Line this season

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Reds and the Giants

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Reds and the Giants:

• Moneyline: NBC Sports Bet is recommending a play on the San Francisco Giants on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Cincinnati Reds at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)