Its Tuesday, April 22 and the Padres (16-7) are in Detroit to take on the Tigers (14-9). Nick Pivetta is slated to take the mound for San Diego against Jack Flaherty for Detroit.

The Tigers won game one of the series yesterday 6-4. Keider Montero started on the mound for the Tigers. He pitched 4.1 innings, giving up five hits, walking four batters, and striking out three, with just three runs earned.

Flaherty is looking to bounce back from a rough performance last time out when he went up against the Brewers. He only made it through 4.2 innings and picked up the loss.

Pivetta is looking to make it three wins in a row against the Tigers tonight and four on the season.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Padres at Tigers

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Padres at the Tigers

The latest odds as of Tuesday:

  • Moneyline: Padres (-105), Tigers (-115)
  • Spread: Tigers 1.5
  • Total: 7.0 runs

Probable starting pitchers for Padres at Tigers

  • Pitching matchup for April 22, 2025: Nick Pivetta vs. Jack Flaherty
    • Padres: Nick Pivetta, (3-1, 1.57 ERA)
      Last outing (4/16): 6.0 Innings Pitched, 1 Earned Runs Allowed, 4 Hits Allowed, Walks, and 6 Strikeouts
    • Tigers: Jack Flaherty, (1-1, 2.53 ERA)
      Last outing (4/15): 4.2 Innings Pitched, 3 Earned Runs Allowed, 5 Hits Allowed, 2 Walks, and 4 Strikeouts

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Top betting trends & insights to know ahead of Padres at Tigers

  • The Padres have won 5 of 7 games following a defeat
  • The Tigers are showing a profit of 4.24 units on the Run Line in their last 5 games at Comerica Park

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Padres and the Tigers

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Padres and the Tigers:

  • Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the San Diego Padres at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Brad Thomas (@MrBradThomas)



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