Oregon vs. Northwestern prediction, odds, time: 2025 college football Week 3 picks from proven model

The fourth-ranked Oregon Ducks will look to open their Big Ten season on a high note when they face the Northwestern Wildcats on Saturday. Oregon is coming off a 69-3 pasting of Oklahoma State, while Northwestern cruised to a 42-7 win over Western Illinois in Week 2. The Ducks (2-0), who won the Big Ten regular-season title at 9-0 last year and finished 13-1, were 5-0 on the road in 2024. The Wildcats (1-1), who placed 16th in the conference at 2-7 and 4-8 overall, were 2-4 on their home field.

Kickoff from Martin Stadium in Evanston, Ill., is at noon ET. Northwestern won the only previous meeting with Oregon, earning a 14-10 win in 1974. The Ducks are 27.5-point favorites in the latest Oregon vs. Northwestern odds, while the over/under for total points scored is 50.5 via SportsLine consensus. Before making any Northwestern vs. Oregon picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 31-19 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has set its sights on Oregon vs. Northwestern. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Oregon vs. Northwestern:

Why Oregon can cover

Redshirt sophomore quarterback Dante Moore is off to a fast start to his collegiate career. So far this season, he has completed 34 of 44 passes (77.3%) for 479 yards and six touchdowns. He has also rushed three times for 42 yards and a score. In the win over Oklahoma State, he completed 16 of 21 passes for 266 yards and three touchdowns.

Senior wide receiver Malik Benson has been Moore’s favorite target. He has seven receptions for 99 yards and two touchdowns. In the 59-13 win over Montana State, he caught five passes for 51 yards and one touchdown. He had two catches for 48 yards and a score in the victory over Oklahoma State. See which team to back at SportsLine. 

Why Northwestern can cover

SMU transfer quarterback Preston Stone powers the Wildcats’ attack. So far this season, he has completed 40 of 65 passes (61.5%) for 406 yards and three touchdowns and four interceptions. His best season came in 2023 at SMU, when he completed 59.9% of his passes for 3,197 yards and 28 touchdowns with six picks. In the win over Western Illinois in Week 2, he completed 21 of 29 passes for 245 yards and three touchdowns.

Senior running back Cam Porter is in his fifth season with the Wildcats. In two games this year, he leads Northwestern in rushing, carrying 18 times for 137 yards (7.6 average) and one touchdown. He has three receptions for 23 yards. Last week in the win over Western Illinois, he carried 12 times for 91 yards and a score. See which team to back at SportsLine.

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How to make Oregon vs. Northwestern picks

SportsLine’s model is going Over on the total, projecting 54 combined points. It also says one side of the spread is the better value. You can only get the pick at SportsLine. 

So who wins Oregon vs. Northwestern, and which side of the spread is the better value? Visit SportsLine now to see which side of the Oregon vs. Northwestern spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.