The 2025 NFL regular season begins this week and we had plenty of injuries occur over the course of the offseason, training camp and preseason. In fantasy football, being up to date on the latest injury news is of the utmost importance. It helps inform managers so they can make the best roster decisions on a weekly basis.
Let’s go over a few names we know are already going to miss Week 1. Houston Texans RB Joe Mixon was sidelined for most of the offseason with nagging foot and ankle issues. He was placed on the PUP list and will be out for at least the first month of the season.
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Same goes for Tampa Bay Buccaneers WR Chris Godwin, who had a second procedure on his ankle early in the offseason. He was activated off the PUP list, but is going to be sidelined for a few weeks. He’s expected to rejoin practice in Week 2.
Tennessee Titans RB Tyjae Spears is on injured reserve and is going to miss at least the first four weeks of the season.
We’ll be tracking all the latest injuries going into Week 1 below. Check back each day for updates!
NFL Week 1 injury report
Quarterback
N/A
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Running Back
De’Von Achane, MIA (calf)
Joe Mixon, HOU (foot/ankle) OUT
Najee Harris, LAC (eye)
Tyjae Spears, TEN (ankle) OUT
Wide Receiver
Justin Jefferson, MIN (hamstring)
Malik Nabers, NYG (toe/shoulder)
Tyreek Hill, MIA (oblique)
Jauan Jennings, SF (calf)
Chris Godwin, TB (ankle) OUT
Darnell Mooney, ATL (shoulder)
Khalil Shakir, BUF (ankle)
Jalen Coker, CAR (quad)
Tetairoa McMillan, CAR (hamstring)
Marvin Mims Jr., DEN (groin)
Jayden Reed, GB (foot)
Hollywood Brown, KC (ankle)
Tight End
Isaiah Likely, BAL (foot)
Mike Gesicki, CIN (hamstring)
Cade Otton, TB (leg)
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