The college football season is back in full swing, and fans can use the latest bet365 bonus code CBSBET365 to access either $300 in bonus bets with the placement of a $5+ bet, or get up to a $1,000 first bet safety net. The Week 2 college football schedule is packed with pivotal matchups, including an in-state rivalry between Iowa and Iowa State. The Hawkeyes have won seven of the last 10 meetings, but the Cyclones walked away with a 20-19 victory last season. The Cyclones are 3.5-point favorites against Iowa, according to the latest Week 2 college football odds at bet365, but SportsLine’s model is backing the Hawkeyes to cover the spread in 58% of simulations.
The model is also backing No. 20 Ole Miss (-9) to cover against Kentucky in an SEC showdown, while the Over (55.5) hits in 71% of simulations in Oklahoma State vs. Oregon. Before locking in your Week 2 college football picks on your favorite betting sites like bet365, be sure to check out the top college football betting picks from SportsLine’s proven computer model. Claim the latest bet365 bonus code here, where new users get $300 in bonus bets, or get up to a $1,000 first bet safety net:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Best Week 2 college football picks:
- Iowa (+3.5) vs. Iowa State
- Ole Miss (-9) vs. Kentucky
- Over 55.5 points in Oklahoma State vs. Oregon
Combining the model’s three picks into a Week 2 college football parlay at bet365 would result in a payout of +595 (risk $100 to win $595). Bet it at bet365 here:
Iowa +3.5 vs. Iowa State
The Hawkeyes are 7-3 in their previous 10 meetings against Iowa State, and have won six consecutive road games against the Cyclones. Iowa State hasn’t defeated Iowa by more than three points since 2005, and the Hawkeyes could drain the clock with their dynamic ground game. Freshman running back Xavier Williams recorded 11 carries for 122 yards and a touchdown in Iowa’s win over Albany last week, and he could find success against an Iowa State defense that gave up 204 rushing yards to the Hawkeyes last season. SportsLine’s model is backing Iowa to cover the spread in 58% of simulations in this rivalry matchup.
Ole Miss -9.5 vs. Kentucky
Kentucky has lost five straight against an SEC opponent, while the Rebels are 14-2 in their last 16 games played in September. Ole Miss is 7-3 in its last 10 meetings against the Wildcats and features one of the nation’s most explosive offenses, which was on full display in last week’s 63-7 win over Georgia State. Quarterback Austin Simmons threw for 341 yards and three touchdowns in his first game as the starter in Lane Kiffin’s offense, and SportsLine’s model projects he’ll exceed 300 passing yards again on Saturday, helping the Rebels cover the spread in 63% of simulations.
Oklahoma State vs. Oregon: Over 55.5 points
Oregon dropped 59 points in its season-opening victory over Montana State behind a strong performance from quarterback Dante Moore. The sophomore signal caller completed 18 of 23 pass attempts for 213 yards and three touchdowns. Meanwhile, Oklahoma State gave up an average of 35.6 points per game last season, which ranked 125th in college football. SportsLine’s model is projecting these two teams will combine for 68 points on average, helping the Over hit in 71% of simulations.
Want more Week 2 college football picks?
You’ve seen the model’s Week 2 college football best bets. Now, get against the spread, total and money-line picks for every Week CFB game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Week 2 college football picks from legendary college football handicapper Bruce Marshall. Visit SportsLine to see his best bets. SportsLine’s Josh Nagel, who is 8-0 In his last eight college football picks, has locked in his best bets for Week 2 right here.
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